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IL-13 Polymorphism (IL-13 rs1800925 (-1055) (C/T) is Associated with Severe Hepatic Fibrosis in Human Schistosomiasis

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dc.contributor.author Rahoud, Siddig A.
dc.contributor.author Mergani, Adil
dc.contributor.author Khamis, Ammar H.
dc.contributor.author Saeed, Osman K.
dc.contributor.author Ali, Qurashi Mohamed
dc.contributor.author C., Christophe
dc.contributor.author Dessein, Alain J.
dc.contributor.author Elwali, Nasr Eldin M. A.
dc.date.accessioned 2022-05-07T11:48:25Z
dc.date.available 2022-05-07T11:48:25Z
dc.date.issued 2015
dc.identifier.uri http://repo.nusu.edu.sd/xmlui/handle/123456789/362
dc.description.abstract An association study of a cohort of 177 Sudanese patients infected with Schistosoma mansoni {82 (46%) males and 95 (54%) females} was conducted to investigate the correlation of four polymorphisms {IFN-γ rs2069705 (C/T), IFN-γ R1 rs11914 (G/T), rs1327474 (A/G), and IL-13 rs1800925 (-1055) (C/T)} to the regression and progression of liver fibrosis 39 months after treatment with praziquantel (PZQ). Regression and progression phenotypes were evaluated by ultrasound. DNA from patients infected with S. mansoni was extracted, purified and amplified by PCR. Allelic typing was done using RFLP, primer extension reaction, DHPLC, and allelic discrimination assays (TAQ-MAN). SDS (Sequence Detection Systems) software was used for genotyping. There was an association between IL-13 rs1800925 T allele and the low grades of periportal fibrosis (PPF) (P = 0.02). No significant association was found between three polymorphisms (IFN-γ rs2069705 (C/T) P = 0.5, rs1327474 (A/G) P = 0.3 and IFN-γ R1 rs11914 (G/T), and PPF as response to PZQ. We conclude that IL-13 rs1800925 T allele is protective against PPF (P = 0.02) en_US
dc.language.iso en en_US
dc.publisher Biological and Chemical Research en_US
dc.subject Periportal fibrosis (PPF) en_US
dc.subject Regression en_US
dc.subject Progression en_US
dc.subject Praziquantel (PZQ) en_US
dc.subject Polymorphisms. en_US
dc.title IL-13 Polymorphism (IL-13 rs1800925 (-1055) (C/T) is Associated with Severe Hepatic Fibrosis in Human Schistosomiasis en_US
dc.type Article en_US

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