Abstract:
Background: Miscarriage is that the commonest complication of pregnancy, defined as rate
of pregnancy loss in women with a missed menstrual period and positive urine pregnancy
and it is occurrence of three consecutive pregnancy losses during the primary trimester.
Material and methods: This study was an analytical case – control study conducted at the
research laboratory of the National university, Khartoum, Sudan during the period July to
November, 2021 and aimed estimate activated partial thromboplastin time(APTT) and
Prothrombin time (PT) level among Sudanese women with recurrent miscarriage. 50
patients attending obstetrics and gynecology unit at Ibrahim Malik teaching hospital and
diagnosed with recurrent spontaneous abortion during the mentioned period were selected
as cases group. In addition to that, 50 apparently healthy women with no history of abortion
and without any other risk factor related to abortion were selected as control group. From
each participant 5ml of venous blood samples were dispensed into sterile containers with
tri-sodium citrate anticoagulant container for APTT and PT measurement. The tests were
performed using semiautomatic device.
Results: In the present study revealed highly significant increase in PT and APTT in case
when compared to control. Also PT, APTT, and INR in cases compared with the age group
the result revealed that; there was an insignificant difference (P.value ≤ 0.05). In addition,
also there were insignificant differences of these parameters when compared with the
number of miscarriage and the history of any disease.
Conclusion: In conclusion, Prothrombin time and activated partial thromboplastin time can
be use as predictive parameter for further miscarriages in cases of recurrent miscarriage.
There is no explanatory cause in women with prolonged PT and APTT
