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Adenomatous Polyposis Coli Gene Polymorphisms in Gliomas

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dc.contributor.author E. Abdelraheem, Nahla
dc.contributor.author Gassoum, Alsadig
dc.contributor.author A. Hamed, Sawsan
dc.contributor.author E. Babiker, Nihad
dc.contributor.author A. Elhassan, Lamyaa
dc.contributor.author A. Arbab, Mohammed
dc.contributor.author Fadl Elmula, Emad
dc.date.accessioned 2022-04-18T08:35:43Z
dc.date.available 2022-04-18T08:35:43Z
dc.date.issued 2021-01-02
dc.identifier.uri http://repo.nusu.edu.sd/xmlui/handle/123456789/318
dc.description.abstract Background: Gliomas are the most common brain neoplasms in adults, accounting for about 70% of primary neoplasms of the central nervous system (CNS). Adenomatous polyposis coli (APC) is a tumor suppressor gene and one of the key players of the Wnt signaling pathway. The Wnt pathway has repeatedly been implicated in brain tumor genesis. Objective: To investigate APC exon 15 polymorphism in gliomas. Materials and methods: DNA was extracted from 61 tumors followed by PCR to amplify fragments of APCs exon 15. Samples showing amplified products were further sequenced. Results: Two polymorphisms {rs41115; G>A at position cDNA. 4859 G>A (5:112175770) leading to codon change of T1493T, and rs456899; G>A at position cDNA. 6260 G>A (5:1121777171)} were detected at the mutation cluster region in 10% of the cases. Conclusion: Adenomatous polyposis coli gene 's exon 15 polymorphism has significant association with carcinogenesis of glioma neoplasms (particularly astrocytomas). en_US
dc.language.iso en en_US
dc.publisher African Journal of Medical Sciences http://ajmsc.info en_US
dc.subject Glioma en_US
dc.subject DNA en_US
dc.subject APC exon 15 gene en_US
dc.title Adenomatous Polyposis Coli Gene Polymorphisms in Gliomas en_US
dc.type Article en_US


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