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Genetic relationship between Hashimoto‘s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto‘s thyroiditis

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dc.contributor.author Subhi, Ohoud
dc.contributor.author Schulten, Hans-Juergen
dc.contributor.author Bagatian, Nadia
dc.contributor.author Al-Dayini, Roa’a
dc.contributor.author Karim, Sajjad
dc.contributor.author Bakhashab, Sherin
dc.contributor.author Alotibi, Reem
dc.contributor.author Al-Ahmadi, Alaa
dc.contributor.author Ata, Manar
dc.contributor.author Elaimi, Aisha
dc.contributor.author Al-Muhayawi, Saad
dc.contributor.author Mansouri, Majid
dc.contributor.author Al-Ghamdi, Khalid
dc.contributor.author Hamour, Osman Abdel
dc.contributor.author Jamal, Awatif
dc.contributor.author Al-Maghrabi, Jaudah
dc.contributor.author Al-Qahtani, Mohammed Hussain
dc.date.accessioned 2022-04-15T11:44:23Z
dc.date.available 2022-04-15T11:44:23Z
dc.date.issued 2020
dc.identifier.uri http://repo.nusu.edu.sd/xmlui/handle/123456789/289
dc.description.abstract Hashimoto’s thyroiditis (HT) is present in the background of around 30% of papillary thyroid carcinomas (PTCs). The genetic predisposition effect of this autoimmune condition is not thoroughly understood. We analyzed the microarray expression profiles of 13 HT, eight PTCs with (w/) coexisting HT, six PTCs without (w/o) coexisting HT, six micro PTCs (mPTCs), and three normal thyroid (TN) samples. Based on a false discovery rate (FDR)- adjusted p-value � 0.05 and a fold change (FC) > 2, four comparison groups were defined, which were HT vs. TN; PTC w/ HT vs. TN; PTC w/o HT vs. TN; and mPTC vs. TN. A Venn diagram displayed 15 different intersecting and non-intersecting differentially expressed gene (DEG) sets, of which a set of 71 DEGs, shared between the two comparison groups HT vs. TN \ PTC w/ HT vs. TN, harbored the relatively largest number of genes related to immune and inflammatory functions; oxidative stress and reactive oxygen species (ROS); DNA damage and DNA repair; cell cycle; and apoptosis. The majority of the 71 DEGs were upregulated and the most upregulated DEGs included a number of immunoglobulin kappa variable genes, and other immune-related genes, e.g., CD86 molecule (CD86), interleukin 2 receptor gamma (IL2RG), and interferon, alpha-inducible protein 6 (IFI6). Upregulated genes preferentially associated with other gene ontologies (GO) were, e.g., STAT1, MMP9, TOP2A, and BRCA2. Biofunctional analysis revealed pathways related to immunogenic functions. Further data analysis focused on the set of non-intersecting 358 DEGs derived from the comparison group of HT vs. TN, and on the set of 950 DEGs from the intersection of all four comparison groups. In conclusion, this study indicates that, besides immune/ inflammation-related genes, also genes associated with oxidative stress, ROS, DNAdamage, DNA repair, cell cycle, and apoptosis are comparably more deregulated in a data set shared between HT and PTC w/ HT. These findings are compatible with the conception of a genetic sequence where chronic inflammatory response is accompanied by deregula tion of genes and biofunctions associated with oncogenic transformation. The generated data set may serve as a source for identifying candidate genes and biomarkers that are practical for clinical application. en_US
dc.language.iso en en_US
dc.publisher PLOS ONE en_US
dc.subject Hashimoto‘s thyroiditis en_US
dc.subject papillary thyroid carcinoma en_US
dc.subject Genetic relationship en_US
dc.title Genetic relationship between Hashimoto‘s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto‘s thyroiditis en_US
dc.type Article en_US

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