Abstract:
Objective: The present study was conducted to assess the impact of oxidative stress on glucose
6 phosphate dehydrogenase (G6PD) and prevalence of anemia among diabetic patients.
Methodology: The study involved 100 adult patients attending Buraidah Central Hospital and
30 healthy controls. Blood samples were collected and analyzed for (G6PD) activity, total
antioxidant status (TAS), fasting blood sugar (FBS), hemoglobin (HGB),red cell( RBCs) count,
hematocrit (HCT), mean cell volume (MCV), mean cell hemoglobin (MCH), and mean cell
hemoglobin concentration (MCHC), hemoglobin A1c (Hb A1c), blood urea, serum creatinine,
and microalbuminuria.
Results: It showed significant correlation between G6PD deficiency and low TAS among diabetics
and significant correlation between low hemoglobin concentration (females < 120 g/L, males
<130 g/L), G6PD deficiency and low concentration of TAS. The prevalence of anemia was 22%
in diabetics.
Conclusion: It can be concluded that there is significant impact of oxidative stress (reduced
TAS) on reduced G6PD level and the low HGB concentration in diabetic patients, that means
oxidative stress of diabetes mellitus is possible cause of G6PD anemia
