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Now showing items 1-20 of 39

New mutation found within OTOR gene involved in deafness in two Sudanese families from Al-Jazirah state- Sudan: using Next Generation Sequencing (NGS)

Sarour, Shimaa M.O.; Zayed, Amel M.; Ibrahim, Mohammed O.M.; Albadry, Diyaaldin E.M.; Hassan, Mohamed M.; Yousif, Ommniyah E.; Salih, Mohamed A. (Bio-Genetics Journal, 2014)

The next generation sequencing technology (NGS) is one of most promising and cost effective alternative for whole genome exome sequencing, which was used to identify unknown mutations among hearing loss patients. New and ...
Computational Detection of Deleterious Single Nucleotide Polymorphisms in Human Adenomatous Polyposis Coli Gene the Gate-Keeper of Colorectal Carcinoma

Salih, Shahenaz S.; Abdelhag, Ibtihal M.; Abdalla, Wafaa M.; Mosad, Altaf S.; Hassan, Mohamed M.; Hassan, Mohamed A. (International Journal of Computational Bioinformatics and In Silico Modeling, 2014)

Colorectal cancer (CRC) is one of the most diffuse cancers worldwide; evidences showed that Adenomatous Polyposis Coli (APC) is a multifunctional tumor suppressor gene that regulates and controls many biological functions; ...
Deleterious Nonsynonymous SNP Found within HLA-DRB1 Gene Involved in Allograft Rejection in Sudanese Family: Using DNA Sequencing and Bioinformatics Methods

Hassan, Mohamed M.; Mohamed, Sofia B.; Hussain, Mohamed A.; Dowd, Amar A. (2015)

Renal transplantation provides the best long-term treatment for chronic renal failure. Singlenucleotide polymorphisms (SNPs) play a major role in the understanding of the genetic basis of many complex human diseases. ...
Bioinformatics approach prediction of nonsynonymous and miRNA-binding site polymorphisms within human SclA9 and Scl22A12 genes

ESHAGE, MOHAMMED A; HAMID, WASAL A.; TAHA, ENTSSAR S.; ABDALLA, REHAB A.; ELHALIM, EMAN M. ABD; HASSAN, MOHAMED M.; MOHAMED, SOFIA B. (EUROPEAN ACADEMIC RESEARCH, 2015)

Single nucleotide polymorphisms (SNPs) have been found in 3’UTRs that disrupt normal miRNA binding or introduce new binding sites and some of these have been associated with disease pathogenesis. This raises the importance ...
Insilico Validation of Babesia Bovis Merozoite Surface Antigen-1, Merozoite Surface Antigen-2b and Merozoite Surface Antigen-2c Proteins for Vaccine and Drug Development

Mohamed, Sofia B; Hassan, Mohamed M. (International Journal of Bioinformatics and Biomedical Engineering, 2016)

The Babesia bovis MSA-1, MSA-2b and MSA-2c are members of the variable merozoite surface antigen (VMSA) family, they are encoded surface proteins that are proposed to mediate the initial attachment of the merozoite to the ...
Bioinformatics Approach for Prediction of Functional Coding/Noncoding Simple Polymorphisms (SNPs/Indels) in Human BRAF Gene

Hassan, Mohamed M.; Omer, Shaza E.; Khalf-allah, Rahma M.; Mustafa, Razaz Y.; Ali, Isra S.; Mohamed, Sofia B. (Advances in Bioinformatics, 2016)

This study was carried out for Homo sapiens single variation (SNPs/Indels) in BRAF gene through coding/non-coding regions. Variants data was obtained from database of SNP even last update of November, 2015. Many bioinformatics ...
A Comprehensive i n Silico Analysis of the Functional and Structural Impact of Non - Synonymous Single Nucleotide Polymorphisms in the Human KRAS Gene

Abdelraheem, Nahla E.; Osman, Lamia O.; Abedlrhman, Samar A.; Ali, Aisha S.; Elsadig, Ahmed H.; El_Tayeb, Ghada M.; Mohamed, Sofia B. (American Journal of Bioinformatics Research, 2016)

The protein product of the normal KRAS gene performs an essential function in normal tissue signaling, and the mutation of a KRAS gene is an essential step in the development of many cancers . Despite the reported ...
Tuberculosis in Sudan: Efficiency of diagnostic techniques commonly used and investigation of some sociodemographic factors which may influence the disease prevalence

Sirelkhatim, Mohammed; Sharaf Eldin, Ghada Sulieman; Fadl Almula, Imad; Babiker, Ahmed; Omer, Rihab Ali (Sudan Medical Monitor, 2016)

Introduction: Tuberculosis (TB) is a bacterial disease that can be spread through the air. It usually attacks the lungs, but it can also attack and damage the other parts of the body such as the brain, kidneys, or ...
Detection and Molecular Characterization of gyrA and gyrB Genes of MDRSalmonella typhi Isolated from Clinical Sample in Sudan

Yasin, Kyakonye; Mwaganyuma, Mwatasa H.; Amir, Ftum M; Hamid, Muzamil M Abdel; Altayb, Hisham N; Hassan, Mohamed M; Hussain, Mohamed A (EC Microbiology, 2017)

Multidrug resistance has contributed widely to increase in morbidity and mortality as it leads to treatment failures and compromising empiric therapy in the management of severe acute infections. In this study, we characterize ...
Bioinformatics Analysis of Single Nucleotide Polymorphism in Multiple Drug Resistance Protein 1 (ABCB1) and Multi - Drug Resistance - Associated Pr otein 1 (ABCC1) in Bos taurus

Mahmoud, Nuha A.; Mohammed, Elham I.; Elshafei, Siham O.; Elsadig, Ahmed H.; Omer, Rihab A.; Mohamed, Sofia B. (American Journal of Bioinformatics Research, 2017)

The ABCB 1 and ABCC1 genes are a transmembrane active efflux pump for a variety of drugs. They are a putative mechanism of multidrug resistance in a range of diseases. It is postulated that ABCB1 and ABCC1 single ...
Molecular characterization and Phylogenetic Analysis of Clostridium botulinum Mosaic Type D/C Isolated from Sudan

Mohamed, Dalia. A.; Abdalla, Mohamed A.; Hassan, Mohamed M.; Ahmed, Abbas M.; Elhaj, Mona O. (American Journal of Microbiological Resear, 2017)

Clostridium botulinum types C and D are related to animal botulism. The disease has been reported in sheep in western Sudan causing economic losses. However, the BoNTs that cause sheep botulism in Sudan have not yet ...
In Silico Analysis of the Structural and Biochemical Features of the Granulocyte - Macrophage Colony Stimulating Factor (GM - CSF), Interleukin - 3 (IL - 3) and Interleukin - 5 (IL - 5) Re ceptors Subunit α

Ibrahim, Elham I. M.; Omer, Rihab Ali; Elsadig, Ahmed H.; Sir Elkhatim, Mohamed; Mohamed, Sofia B. (American Journal of Bioinformatics Research, 2017)

Computational analysis has become an indispensable bioinformatics approaches for the characterization of proteins regarding the physicochemical properties, prediction of signal peptides and 3D stru ...
Prevalence and Risk Factors Associated with Bovine Trypanosomosis Using Conventional Methods and Polymerase Chain Reaction (PCR) in the Blue Nile State, Sudan

Elkhazeen, Khalda Abbass; Yaji, Rihab Ali; Salih, Diyaa Eldeen Ahmed; Omer, Rihab Ali; Abdelgadir, Atif Elamin (Journal of Applied Science And Research, 2017)

This study was conducted to determine the prevalenc e and associated risk factors of bovine trypanosomosis in cattle using conventional methods and Polymerase Chain Reaction (PCR) in the Blue Nile ...
First Complete Genome Sequence of Methicillin-Resistant Staphylococcus aureus Strain SO-1977 Isolated from Khartoum, Sudan

Mohamed, Sofia B.; Ali, Mohamed S.; Alamir, Faisal M.; Alyas, Tahani B.; Ahmed, Abdallah E.; Seed, Almeen O.; Omer, Rihab A. (American Society for Microbiology, 2017)

Methicillin-resistant Staphylococcus aureus is increasingly becoming re- sistant to most antibiotics and consequently has become a challenging public health problem in Sudan. The present study documented the first ...
Prevalence of Schistosoma haematobium among School Children in Al-Lamab Bahar Abiad Area, Khartoum State, Sudan 2017: A Cross Sectional Study

Osman, Rowa M.; Eisa, Nusaiba S.; Nasr, Awad A.; Ali, Omer O. S.; Siddig, Emmanuel Edwar; Mohamed, Nouh S. (EC MICROBIOLOGY, 2018)

Schistosomiasis is the one of the World Health Organization’s most neglected disease. It is a major tropical and subtropical disease commonly found mainly in the developing countries. A cross sectional descriptive study ...
DNA Extraction and PCR Detection of G.Lamblia Cyst from Human Fecal Samples in Some Sudanese Suspected Patients

Elnazeer, Anas Mahadi; Elssir, Abdallha; Omer, Rihab Ali; Mustafa, Mubark; Elmalik, Khitma Hassan (American Journal of Zoology, 2018)

The study aim to evaluate guanidine hydrochloride (HCL) as DNA extraction method from Giardia Cyst in human fecal samples and PCR detection using triose phosphate isomerase gene (tpi). Atotal of 30positive fecal samples ...
Detection of Drug Resistant Genes of Mycobacterium tuberculosis in Sudanese Tuberculosis Patients in Khartoum State Using Multiplex PCR

Farah Aldour, Mohammed Saad Mohammed; Elhussein, Abdel Rhim Mohammed; Elkhidir, Isam Mohammed; Tayeib, Seif Eldin; Mohammed Khair, Osama; Mohamed, Nouh S.; Enan, Khalid A. (EC MICROBIOLOGY, 2018)

Tuberculosis is a common contiguous disease caused by M. tuberculosis. With an estimated 9 million new cases and 2 million deaths every year, tuberculosis represents one of the most serious infectious diseases worldwide. ...
Molecular detection and characterization of Theileria spp. infecting cattle in Sennar State, Sudan

Mohamed, Sofia B.; Alagib, Atif; AbdElkareim, Tahani B.; Hassan, Mohamed M.; Johnson, Wendell C.; Hussein, Hala E.; Taus, Naomi S.; Ueti, Massaro W. (Parasitology Research, 2018)

Tropical theileriosis is a serious animal disease transmitted by tick vectors. The agents of theileriosis are obligate intracellular parasites that cause mild to severe disease in the mammalian host. Tropical theileriosis ...
A Comprehensive Analysis on the Genetic Diversity of Plasmodium Falciparum MSP-1 Field Isolated from Different Regions in Sudan. A Cross-Sectional Study

Mohamed, Nouh S.; Albsheer, Musab M. Ali; Abdelbagi, Hanadi; Siddig, Emanuel E.; Mohamed, Mona A.; Muneer, Mohamed S. E.; Elbasheir, Mohamed M. (EC MICROBIOLOGY, 2018)

Malaria caused by P. falciparum still posing a great risk in sub Saharan African countries. Persistence of malaria is considered as a major threat to health and blocks the path to economic development for individuals, ...
First detection of Echinococcus granulosus sensu stricto (G1) in dogs in central Sudan

Omer, Rihab Ali; Daugschies, Arwid; Gawlowska, Sandra; Elnahas, Ayman; Kern, Peter; Bashir, Sofia; Ali, Mohammed Sir Alkhatim; Osman, Amin; Romig, Thomas (Parasitology Research, 2018)

Eighty-four stray dogs shot as a part of a governmental rabies control program in two neighboring towns of central Sudan were examined for the presence of Echinococcus spp. and other intestinal helminths. Echinococcus ...

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