• Functional and Genetic Studies in Type 2 Diabetes and Obesity 

  Seed Ahmed, Mohammed Hamza Z. E (Karolinska Institutet, 2013)

  Type 2 diabetes (T2D) and obesity are highly prevalent disorders reflecting a complex interplay of genetics, epigenetics, and environment. They constitute serious health problems and lead to significant morbidity and ...
• Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats 

  Seed Ahmed, Mohammed; Kovoor, Abraham; Nordman, Sofia; Abu Seman, Norhashimah; Gu, Tianwei; Efendic, Suad; Brismar, Kerstin; Östenson, Claes-Göran; Gu, Harvest F. (Islets, 2012)

  Adenylyl cyclase 3 (AC3) is expressed in pancreatic islets of the Goto-Kakizaki (GK) rat, a spontaneous animal model of type 2 diabetes (T2D), and also exerts genetic effects on the regulation of body weight in man. In ...
• Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: Knockdown of SCOT inhibits insulin release in rat insulinoma cells 

  Hasan, Noaman M.; Longacre, Melissa J.; Seed Ahmed, Mohammed; Kendrick, Mindy A.; Gu, Harvest; Ostenson, Claes-Goran; Fukao, Toshiyuki; MacDonald, Michael J. (Archives of Biochemistry and Biophysics, 2010)

  Succinyl-CoA:3-ketoacid-CoA transferase (SCOT) is a mitochondrial enzyme that catalyzes the reversible transfer of coenzyme-A from acetoacetyl-CoA to succinate to form acetoacetate and succinyl-CoA. mRNAs of SCOT and ATP ...
• Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer’s Disease 

  Tajeddinn, Walid; Persson, Torbjorn; Calvo-Garrido, Javier; Seed Ahmed, Mohammed; Maioli, Silvia; Vijayaraghavan, Swetha; Kazokoglu, Mehmet Selim; Parrado-Fernandez, Cristina; Yoshitake, Takashi; Kehr, Jan; Francis, Paul; Winblad, Bengt; Hoglund, Kina; Cedazo-Minguez, Angel; Aarsland, Dag (Journal of Alzheimer’s Disease, 2016)

  Serotonin (5-HT) plays a central role in the integrity of different brain functions. The 5-HT homeostasis is regulated by many factors, including serotonin transporter (SERT), monoamine oxidase enzyme (MAO), and several ...
• Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies 

  Haytural, Hazal; Lundgren, Jolanta L; Kose, Tansu B; Jordà-Siquier, Tomàs; Kalcheva, Marinela; Seed Ahmed, Mohammed; Winblad, Bengt; Sundström, Erik; Barthet, Gael; Tjernberg, Lars O.; Frykman, Susanne (Frontiers, 2019)

  The use of human post-mortem brain material is of great value when investigating which pathological mechanisms occur in human brain, and to avoid translational problems which have for example been evident when translating ...
• In transition: current health challenges and priorities in Sudan 

  Charani, Esmita; Cunnington, Aubrey J; Yousif, AlaEldin H A; Seed Ahmed, Mohammed; Ahmed, Ammar E M; Babiker, Souad; Badri, Shahinaz; Buytaert, Wouter; Crawford, Michael A; Elbashir, Mustafa I; Elhag, Kamal; Elsiddig, Kamal E; Hakim, Nadey; Johnson, Mark R; Miras, Alexander D; Swar, Mohamed O; Templeton, Michael R; Taylor-Robinson, Simon David (BMJ Global Health, 2019)

  A recent symposium and workshop in Khartoum, the capital of the Republic of Sudan, brought together broad expertise from three universities to address the current burden of communicable and non-communicable diseases ...
• Genetic Association of Adrenergic Receptor Alpha 2a with Obesity and Type 2 Diabetes 

  La˚ ngberg, Ewa-Carin; Seed Ahmed, Mohammed; Efendic, Suad; Gu, Harvest F.; Ostenson, Claes-Goran (Obesity, 2013)

  Objective: The sympathetic nervous system (SNS) is linked to glucose, lipid, and protein metabolism. The a2A-adrenergic receptor (ADRA2A) is involved in the SNS and mediates inhibition of insulin secretion and lipolysis. ...
• Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male GotoKakizaki Rats, a Model of Type 2 Diabetes 

  Seed Ahmed, Mohammed; Pelletier, Julien; Leumann, Hannes; Gu, Harvest F.; Östenson, Claes-Göran (PLOS ONE, 2015)

  Protein kinase C (PKC) is a family of protein kinases controlling protein phosphorylation and playing important roles in the regulation of metabolism. We have investigated expression levels of PKC isoforms in pancreatic ...
• Association of Platelet Serotonin Levels in Alzheimer’s Disease with Clinical and Cerebrospinal Fluid Markers 

  Tajeddinn, Walid; Fereshtehnejad, Seyed-Mohammad; Seed Ahmed, Mohammed; Yoshitake, Takashi; Kehr, Jan; Shahnaz, Tasmin; Milovanovic, Micha; Behbahani, Homira; Hoglund, Kina; Winblad, Bengt; Cedazo-Minguez, Angel; Jelic, Vesna; Jaremo, Petter; Aarsland, Dag (Journal of Alzheimer’s Disease, 2016)

  Introduction: Serotonin (5-HT) is involved in the pathology of Alzheimer’s disease (AD). Objective: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers ...
• Adenylate cyclase 3: a new target for anti-obesity drug development 

  Wu, L.; Shen, C.; Seed Ahmed, M.; Östenson, C.-G.; Gu, H. F. (obesity reviews, 2016)

  Obesity has become epidemic worldwide, and abdominal obesity has a negative im- pact on health. Current treatment options on obesity, however, still remain limited. It is then of importance to find a new target for ...
• Nerve conduction and its correlations with duration of diabetes mellitus and glycosylated haemoglobin in type 2 diabetes mellitus (T2DM) 

  Hamid, Wissam S; Ahmed, Humeda S; Osman, Mona A; Babiker, Rasha (Journal of Endocrinology, Metabolism and Diabetes of South Africa, 2021)

  Background: Diabetic neuropathy is one of the most common microvascular complications associated with diabetes mellitus. Diabetic peripheral neuropathy (DPN) has been linked to hyperglycaemia and long duration of uncontrolled ...
• SUDANESE PHARMACY STUDENTS: CAREER INTENTIONS, EXPECTATIONS AND FACTORS AFFECTING THEIR CHOICES 

  Alhemadey, Hebatallah; Mousnad, Mohamed Awad; Saeed, Ali Awadallah; Hamid, Azza (Universal Journal of Pharmaceutical Research, 2020)

  Objectives: Pharmacy is a profession with wide careers. The desires to study pharmacy affect selection of pharmacy careers. Despite that in the last years pharmacy careers had developed and expanded , majority of the ...
• Why Did Sudanese End Stage Renal Failure Patients Refuse Renal Transplantation? 

  Banaga, Amin S.; Mohammed, Elaf B.; Siddig, Rania M.; Salama, Diana E.; Elbashir, Sara B.; Khojali, Mohamed O.; Babiker, Rasha A.; Elmusharaf, Khalifa; Homeida, Mamoun M. (Open Journal of Nephrology, 2015)

  Renal transplantation remains the most effective treatment of End Stage Renal Failure (ESRF). In this cross sectional study we explore the reasons behind refusal of renal transplantation among adults’ Sudanese haemodialysis ...
• Prevalence and Presentation of Tuberculosis among Hemodialysis Patients in Khartoum, Sudan 

  Banaga, Amin S. I.; Siddiq, Nihad K.; Alsayed, Randa T.; Babiker, Rasha; Elmusharaf, Khalifa (Saudi Journal of Kidney Diseases and Transplantation, 2016)

  Tuberculosis (TB) is a major health problem in the developing countries. There are limited data about the prevalence of TB patients on maintenance hemodialysis (HD) in Sudan. The aim of this study is to identify the ...
• Potential Role of Acacia Senegal (Gum Arabic) as Immunomodulatory Agent among newly diagnosed COVID 19 Patients: A structured summary of a protocol for a randomised, controlled, clinical trial 

  Kaddam, Lamis; Babiker, Rasha; Ali, Sara; Satti, Shahinaz; Ali, Nour; Elamin, Maha; Mukhtar, Mowaia; Elnimeiri, Mustafa; Saeed, Amal (Trials, 2020)

  Objectives: To investigate the potential efficacy of Acacia Senegal extract Gum Arabic (GA) supplementation as immunomodulatory and anti-inflammatory dietary intervention among newly diagnosed COVID 19 Sudanese patients. ...
• Metabolic effects of Gum Arabic (Acacia Senegal) in patients with Type 2 Diabetes Mellitus (T2DM): Randomized, placebo controlled double blind trial 

  Babiker, Rasha; Elmusharaf, Khalifa; Keogh, Michael B.; Banaga, Amin S. I.; Saeed, Amal M. (Functional Foods in Health and Disease, 2017)

  Background: Gum Arabic (GA) is a water-soluble dietary fiber, indigestible to both humans and animals. While GA currently does not have any therapeutic potential, it has nutritional value and some effects on metabolism ...
• Effects of gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial 

  Babike, Rasha; Merghani, Tarig H.; Elmusharaf, Khalifa; Badi, Rehab M.; Lang, Florian; Saeed, Amal M. (Nutrition Journal, 2012)

  Background: Gum Arabic (acacia Senegal) is a complex polysaccharide indigestible to both humans and animals. It has been considered as a safe dietary fiber by the United States, Food and Drug Administration (FDA) since ...
• Effect of Gum Arabic (Acacia Senegal) supplementation on visceral adiposity index (VAI) and blood pressure in patients with type 2 diabetes mellitus as indicators of cardiovascular disease (CVD): a randomized and placebo-controlled clinical trial 

  Babiker, Rasha; Elmusharaf, Khalifa; Keogh, Michael B.; Saeed, Amal M. (Lipids in Health and Disease, 2018)

  Background: There is a strong association between cardiometabolic risk and adipose tissue dysfunction with great consequences on type 2 diabetic patients. Visceral Adiposity Index (VAI) is an indirect clinical marker of ...
• Causes of end stage renal failure among haemodialysis patients in Khartoum State/Sudan 

  Banaga, Amin S. I.; Mohammed, Elaf B.; Siddig, Rania M.; Salama, Diana E.; Elbashir, Sara B.; Khojali, Mohamed O.; Babiker, Rasha A.; Elmusharaf, Khalifa; Homeida, Mamoun M. (BMC Research Notes, 2015)

  Background: End stage renal failure (ESRF) has become a major health problem in Sub Saharan Africa (SSA). There were limited data about causes of ESRF in the Sudan. Methods: This is a cross sectional hospital based ...
• Characterization of Pineal Region in MR Brain Images using Texture Analysis 

  Hassib, Mazin B. A.; Hassib, Ahmed B. A.; Ibrahim, Abbas K. A.; Alamin, Asma I. A.; Garelnabi, M. E. M. (IOSR Journal of Applied Physics (IOSR-JAP), 2018)

  The classification processes of MRI brain were defining the corpus,pineal gland, techunum, and third ventricle were carried out using Interactive Data Language (IDL) program as platform for the generated codes. The result ...

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